Baghdad Science Journal | Current Issue

Volume 14 - Issue 2

(25 Articles)

(P) ISSN:2078-8665

(E) ISSN:2411-7986

 English  /  عربي


2017 > Issue 2 > Volume 14

Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy

Assist. Lecturer Hussein Abdul jabbar Alsamarrai | Assist. Prof. Khalaf F. Alsamarrai

Abstract:

A New Spectrophotometric Methods are improved for determination Metronidazole (MTZ) and Metronidazolebenzoate (MTZB) depending on1STand 2nd derivative spectrum of the two drugs by using ethanol as a solvent. Many techniques were proportionated with concentration (peak high to base line, peak to peak and peak area). The linearity of the methodsranged between(1-25µg.ml-1) is obtained. The results were precise and accurate throw RSD% were between (0.041-0.751%) and (0.0331-0.452%), Rec% values between (97.78, 101.87%) and (98.033-102.39%) while the LOD between (0.051-0.231 µg.ml-1) and (0.074-1.04 µg.ml-1) and LOQ between (0.170-0.770µg.ml-1) and (0.074-0.313 µg.ml-1) of (MTZ) and of (MTZB) respectively. These Methods were successfully applied to determination of (MTZ) and (MTZB) in the pharmaceutical preparatio; ns.

Keywords:

Spectrophotometric, determination, Metronidazole and Metronidazole Benzoate, First and second order derivative of spectrum.

04/06/2017 | Total Downloads:(19) | Doi:( http://dx.doi.org/10.21123/bsj.2017.14.2.0320 )