Baghdad Science Journal | Current Issue

Volume 15 - Issue 3

(18 Articles)

(P) ISSN:2078-8665

(E) ISSN:2411-7986

 English  /  عربي


2018 > Issue 3 > Volume 15

Biological Activity of Levan Produced from Rhizospheric Soil Bacterium Brachybacterium phenoliresistens KX139300

Mohammad M.F. Al-Halbosiy| Zaid A. Thabit| Safaa Al-Deen A. S.Al-Qaysi| Tarek A.A. Moussa

Abstract:

Levan is an exopolysaccharide produced by various microorganisms and has a variety of applications. In this research, the aim was to demonstrate the biological activity of levan which produced from B. phenoliresistens KX139300. These were done via study the antioxidant, anti-inflammatory, anticancer and antileishmanial activities in vitro. The antioxidant levan was shown 80.9% activity at 1250 µg/mL concentration. The efficient anti-inflammatory activity of 88% protein inhibition was noticed with levan concentration at 35 µg/mL. The cytotoxic activity of levan at 2500 µg/mL concentration showed a maximum cytotoxic effect on L20B cell line and promastigotes of Leishmani tropica. Levan has dose-dependent anticancer and antileishmanial activities. An addition to the antioxidant, anti-inflammatory and anticancer potential activities of levan, it can be concluded that levan produced from B. phenoliresistens can efficiently be applied as an antileishmanial agent..

Keywords:

Anticancer; Anti-inflammatory; Antioxidant; Antileishmanial; Brachybacterium phenoliresistens; Levan..

Published Date:13/09/2018 | Total Downloads:(30) | Doi:( http://10.21123/bsj.2018.15.3.0238 )